COMPOSITION AND METHODS FOR PREVENTING OR REDUCING THE INCIDENCE OF TRANSIENT ISCHEMIC ATTACKS

摘要

A composition and method for preventing or reducing the incidence of a transient ischemic attack in a subject at risk for developing a stroke comprises orally administering to the subject a prophylactically effective amount of a pharmaceutical composition comprising an ASIC la inhibitor capable of penetrating the blood-brain barrier. Preferred ASIC la inhibitors for use in the disclosed methods include amiloride and amiloride analogs.