STRUCTURALLY SIMPLIFIED DIAZONAMIDE ANALOGS AS ANTIMITOTIC AGENTS

摘要

The present invention relates to medicine and in particular to the treatment of metastatic tumors, more particularly to antimitotic agents and microtubule polymerization inhibitors. Even more particularly, the invention relates to novel analogs of natural antimitotic agent diazonamide A and pharmaceutical compositions thereof and the use of the novel analogs as inhibitors of microtubule polymerization. Formula (I):