A kit containing asialo-α1-acid glycoprotein as a marker for diagonising progressive chronic liver disease and liver fibrosis and the method of using thereof

摘要

The present invention is to quickly and conveniently test for liver disease in the early stages, and more specifically, a monoclonal antibody against alpha-1 acid glycoprotein, and asialo alpha-1 acid as a marker of liver function impairment in a sample using the antibody. By measuring the concentration of glycoprotein (AsAGP), it relates to a diagnostic kit for tracking the degree of progressive chronic hepatitis and liver fibrosis, which are early stages of liver disease, and its use. In addition, the present invention relates to a single antibody AGP601 against alpha-1 acid glycoprotein produced by the fusion cell line deposited under the accession number KCTC13998BP and horseradish peroxidase (HRP), and binds to asialo alpha- A kit and immunochromatography for specifically determining the degree of progressive chronic hepatitis and hepatic fibrosis from a blood sample, containing a HRP-RCAII (Ricinus communis agglutinin II) conjugate or Gold-RCAII conjugate that specifically binds to monoacid glycoprotein A graph strip is provided.