Use of alternating electric fields to enhance brain-blood barrier permeability

摘要

Certain substances (such as large molecules) that cannot normally cross the blood-brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, where the frequency of the alternating electric field is adjusted to enhance the permeability of the blood-brain barrier. is chosen In some embodiments, the frequency of the alternating electric field is less than 190 kHz (eg, 100 kHz). An increase in the permeability of the blood-brain barrier allows the substance to cross the blood-brain barrier.