IMMUNOGENIC CONJUGATE INTENDED TO INDUCE AN IMMUNE RESPONSE DIRECTED AGAINST INTERLEUKIN-6

摘要

The present invention relates to an immunogenic conjugate comprising: - a carrier protein and - at least one polypeptide having at most 100 amino acids comprising a sequence of 5 to 50 amino acids of interleukin-6 (IL-6) or of the IL-6 receptor (IL-6R), or a variant sequence having at least 75% identity with the sequence of 5 to 50 amino acids of IL-6 or of IL-6R, in which the polypeptide is covalently bonded to the carrier protein and the carrier protein is a non-toxic mutant diphtheria toxin.