SYSTEM AND METHOD TO SELECT PHAGE THERAPY BASED ON TIME AND LOCATION

摘要

A method of selecting a phage formulation is described wherein the method comprises storing bacterial infection/contamination data at one or more treatment locations in a spatio-temporal infection database, the database comprising at least one of the following data fields: (1) a clinical indication, (2) a bacteria identification, (3) a clinical outcome, (4) a phage resistance status, (5) a phage susceptibility profile, (6) an antibiotic susceptibility profile, and/or (7) a lab test result relating to any one of (1)-(6); identifying one or more phage suitable for inclusion in the phage formulation by analyzing the data fields of (1)-(7) in the database to identify to one or more infections associated with a treatment location during a historical time period based at least on one or more of a frequency of infections/contamination, a geographic clustering of infections/contamination, and/or phage usage data; and generating a selected list of phage to be included in the phage formulation. Uses of formulations are also described.