Hla-a1 - or hla-cw7 - a T-cell receptor that recognizes restricted mage

摘要

Problem to be solved: to provide a treatment or prevention method of cancer in a host.(a) provide an isolated or purified T cell receptor (TCR) that has antigenicity to mage-a12 in relation to hla-a1 in relation to melanoma antigen family a (MAGE a) - 3, or b) hla-cw7.The present invention further provides the associated polypeptides and proteins, and associated nucleic acids, recombinant expression vectors, host cells and cell populations.The antibody associated with the TCR, the antigen binding portion, and the pharmaceutical composition of the invention are further provided by the present invention.Methods of detecting the presence of cancer in the host and methods of treating or preventing cancer in the host are further provided by the present invention.No selection