Medicinal composition containing a complex of chemically modified siRNA and schizophyllan

摘要

It is an object of the present invention to provide a chemically modified siRNA having a high degree of resistance to RNase and a RNAi activity effectively, when chemically combined siRNA with a polydeoxyadenylate added to the 5 'end of the sense chain.In a modified siRNA containing a polydeoxyadenylate at the 5 'terminal of the sense chain, the dinucleotide sequence of Ca, UA, and UG in the nucleotide sequence of the sense chain, and Ca, UA in the eighth and later base sequences of the antisense chain from the 5' end Specific chemical modifications to the dinucleotide sequence of UG and UG can solve the problem.