PHARMACEUTICAL COMPOSITION CONTAINING COMPLEX OF CHEMICALLY-MODIFIED SIRNA AND SCHIZOPHYLLAN

摘要

The purpose of the present invention is to provide chemically-modified siRNA having polydeoxyadenylic acid added to the 5' end of the sense strand thereof, wherein when complexed with schizophyllan, the chemically-modified siRNA is highly resistant to RNase and effectively exhibits RNAi activity. The problem is solved by modified siRNA having polydeoxyadenylic acid at the 5' end of the sense strand thereof, wherein a particular chemical modification is applied to CA, UA, and UG dinucleotide sequences in the base sequence of the sense strand thereof, and CA, UA, and UG dinucleotide sequences in the base sequence beyond the eighth base from the 5' end of the antisense strand thereof.