Liposomal-gold nanoparticles for drug delivery into the brain

摘要

The present invention discloses targeting microRNAs as a potential therapeutic target for cancer, more particularly glioblastoma (GBM). It discloses targeting microRNAs with gold-nanoliposomes labeled with brain targeting-peptides inducing a significant cell growth arrest and inhibition of miRNA-92b, an aberrantly abundant miRNA found in GBM cells. Furthermore, it delivers gold-nanoliposomes to the brain by crossing the blood brain barrier (BBB) and reaching cancer tumors.