An object of the present invention is to effectively induce cancer cell apoptosis using the anti-TRAIL-Rl antibody(ies) and the anti-TRAIL-R2 antibody(ies) and to reduce the toxicity imposed on normal cells. The present invention relates to recombinant obligate anaerobic Gram-positive bacteria that comprise a nucleic acid encoding a fusion protein comprising 3 or more anti-TRAIL-Rl single-chain antibodies and/or 3 or more anti-TRAIL-R2 single-chain antibodies, in an expressible state.
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