Recombinant obligate anaerobic Gram-positive bacteria

摘要

An object of the present invention is to induce effective cancer cell death by anti-TRAIL-R1 antibody and anti-TRAIL-R2 antibody and to reduce toxicity to normal cells. A recombinant obligate anaerobic Gram-positive bacterium containing a nucleic acid encoding a fusion protein comprising three or more anti-TRAIL-R1 single chain antibodies and / or three or more anti-TRAIL-R2 single chain antibodies.