TUBULAR SHAPED ELONGATED CATHETER DEVICE ASSEMBLIES FOR INTERACTING WITH COMPONENTS OF BODILY FLUIDS, METHOD FOR RECOVERING CELLS, CELL AGGREGATES AND EXOSOMES FROM A TUBULAR SHAPED ELONGATED CATHETER DEVICE AND SMART TUBULAR SHAPED ELONGATED CATHETER DEVICE ASSEMBLIES FOR MONITORING INTERACTION WITH COMPONENTS OF BODILY FLUIDS

摘要

The present invention relates to a tubular shaped elongated catheter device assembly comprising with a distal and a proximal end, comprising an intraluminal distal segment and an extraluminal proximal segment, comprising one or more chemical and/or biological agents, for interaction with bodily fluids of luminal organs, wherein the intraluminal segment comprises at least one expandable cross-sectional area which in its expanded state is smaller than the cross-sectional area of the luminal target site, and wherein at least the expandable portion of the intraluminal segment is capable of interacting with at least one component of the bodily fluid via an interactive contact surface, as well as corresponding methods of treatment. Also envisaged is a method of manufacturing the device assembly. The present invention further relates to a method for recovering cells, aggregates of cells and/or tumor cell derived exosomes and/or proteins and/or nucleic acids from a tubular shaped elongated catheter device assembly comprising one or more chemical and/or biological agents wherein said device being capable of recruiting said elements and thereby removes them from circulation, was implanted in a blood or lymphatic vessel, as well as corresponding methods of treatment. Also envisaged are cells, proteins or nucleic acids obtained from the method, methods of diagnosing cancer, a method of identifying a target cell or protein and a method of monitoring the effect of a disease treatment. In addition, the present invention relates to a tubular shaped elongated catheter device assembly comprising one or more chemical and/or biological agents wherein the device is capable of interacting with certain components of bodily fluids such as circulating cells, cell aggregates, exosomes or immunologic cells, wherein said device is designed to allow a read out and/or monitoring of the device with respect to the recruiting of or interaction with said components. Further envisaged is such a tubular shaped elongated catheter device assembly use in diagnosing and/or monitoring a disease and a corresponding method of monitoring the effect of a disease treatment.