SYNTHESIS OF 2-(SUBSTITUTEDPHENYL)-5-(SUBSTITUTEDHETEROARYL)- 1H-BENZIMIDAZOLE DERIVATIVES AND INVESTIGATION OF THEIR BIOLOGICAL EFFECTS

摘要

The invention is related to the synthesis of 2-((5-(2-(4-Substitutedphenyl)-1H-benzo[d]imidazole-6-yl)-1,3,4-oxadiazole-2-yl)thio)-1-(4substitutedpiperazine-1-yl)-ethane-1-one derivative compounds and investigation of their biological effects. Cytotoxicity of the obtained compounds on 5 different cancer cell lines was evaluated and their selectivity indices were calculated.