TERLIPRESSIN-OCTADECANEDIOIC ACID CONJUGATE FOR VASOCONSTRICTIVE THERAPY

摘要

In an aspect, disclosed herein is a compound characterized by formula (FX1): A¹—X¹—X²—A² (FX1); wherein: A¹ is a carboxylic acid group, a carboxylate anion, or a carboxylate ester; X¹ is a substituted or unsubstituted and saturated or unsaturated C₁-C₅₀ aliphatic group; X² is a linker group selected from the group consisting of a direct bond, an organic group, -0-, -S-, -S(=O)-, -S(=O)₂-, -S-S-, -N=, =N-, -N(H)-, -N=N-N(H)-, -N(H)-N=N-, -N(OH)-, -N(=O)-, and any combination thereof; and A² is a peptide, the peptide being terlipressin or a substituted or unsubstituted derivative, a substituted or unsubstituted natural or synthetic analogue, a substituted or unsubstituted variant, a substituted or unsubstituted isomer, or a substituted or unsubstituted fragment of terlipressin.