Humanized programmed cell death: non human animals with 1 gene

摘要

Humanized program cell death.There are provided methods and compositions for non-human animals and their creation and use, where the non human animals include humanization of the programmed cell death 1 (PDCD1) gene.In some embodiments, the non human animal may be described as having a gene modification to the endogenous PDCD1 gene such that the non human animal expresses a PD-1 polypeptide comprising a human portion and an endogenous portion (e.g., a non human portion).The present invention is rodent expressing, for example, a PD-1 polypeptide, and provides a rodent with the PD-1 polypeptide having a human portion and an endogenous portion.No selection