COMPOSITIONS AND METHODS FOR DIAGNOSING LYME DISEASE AND PREDICTING ELIMINATION OF LYME DISEASE-CAUSING SPIROCHETES AFTER TREATMENT

摘要

FIELD: medicine.;SUBSTANCE: group of inventions relates to the diagnosis and prognosis of Lyme disease. The composition for the diagnosis or prognosis of Lyme disease contains 5 isolated FlaB peptides with Borrelia T-cell epitopes having amino acid sequences SEQ ID NO: 1-5; 13 isolated DbpB peptides with a Borrelia T-cell epitope having the amino acid sequence SEQ ID NO:6-18; 13 isolated peptides p66 with a T-cell epitope of Borrelia having amino acid sequences SEQ ID NO:19-31; 2 isolated OspC peptides with a Borrelia T-cell epitope having the amino acid sequences SEQ ID NO:32-33. Also disclosed is a method for detecting Lyme disease in a subject, a composition containing a set of nucleic acids encoding peptides, a set of nucleic acid-based vectors for host cell transformation, and a host cell for the expression of nucleic acids. ;EFFECT: improved diagnostic and prognostic assessment of Lyme disease. ;43 cl, 1 dwg, 7 tbl, 1 ex