Medicament for treating influenza characterized by combining a Cap-dependent endonuclease inhibitor and an anti-influenza drug

摘要

A medicament characterized in that (A) a compound represented by the formula (I):; its pharmaceutically acceptable salt, or a solvate thereof,whereinP is hydrogen or a group to form a prodrug;A¹ is CR^1AR^1B, S or O;A² is CR^2AR^2B, S or O;A³ is CR^3AR^3B, S or O;A⁴ is each independently CR^4AR^4B, S or O;the number of hetero atoms among atoms constituting the ring which consists of A¹, A², A³, A⁴, nitrogen atom adjacent to A¹ and carbon atom adjacent to A⁴ is 1 or 2;R^1A and R^1B are each independently hydrogen, halogen, alkyl or the like;R^2A and R^2B are each independently hydrogen, halogen, alkyl, or the like;R^3A and R^3B are each independently hydrogen, halogen, alkyl, or the like;R^4A are each independently hydrogen, halogen, alkyl, or the like;R^4B are each independently hydrogen, halogen, alkyl, or the like;R^3A and R^3B may be taken together with an adjacent carbon atom to form non-aromatic carbocycle or non-aromatic heterocycle;n is any integer of 1 to 2; andR¹ is; or the like,is combined with (B) compound(s) having an anti-influenza activity, its pharmaceutically acceptable salt or a solvate thereof and/or an antibody having anti-influenza activity, is useful for treating or preventing influenza.