SIX-MEMBERED AND FIVE-MEMBERED AROMATIC RING DERIVATIVE CONTAINING NITROGEN HETEROATOMS WHICH CAN BE USED AS SHP2 INHIBITOR

摘要

Provided is the compound having SHP2-inhibiting activity represented by formula (I), a preparation method thereof, a composition containing said compound, and an application thereof as an SHP2 inhibitor and a pharmaceutical use thereof; in formula (I), the ring A is selected from a 3–10-membered alicyclic ring, a 6–10-membered aromatic ring, a 5–10-membered alicyclic heterocyclic ring, and a 5–10-membered aromatic heterocyclic ring; the ring B is selected from the group consisting of a 5–8-membered monocyclic heterocyclic ring, a 6–12-membered bicyclic heterocyclic ring, a 10–18-membered tricyclic heterocyclic ring, and a 14–20-membered tetracyclic heterocyclic ring; each of X¹, X², and X³ is independently selected from C and N; each of X⁴, X⁵, X⁶, X⁷, and X⁸ is independently selected from CR¹, N, and NR²; L is selected from a covalent bond, S, CR³R⁴, NR⁰, S(O)₂, S(O), and O.