首页> 外国专利> NEW CHEMICAL COMPOUND CONTAINING ACTIVE ENANTIOMETER S-(-) KETOROLAC TROMETHAMINE FOR THE TREATMENT OF PAIN

NEW CHEMICAL COMPOUND CONTAINING ACTIVE ENANTIOMETER S-(-) KETOROLAC TROMETHAMINE FOR THE TREATMENT OF PAIN

机译:含有活性对映计的新化学化合物S - ( - )Ketorolac Tromethamine用于治疗疼痛

摘要

The invention relates to a novel chemical compound characterized in that it contains the active enantiomer S-(−) ketorolac tromethamine combined with other pharmaceutically acceptable adjuvants or excipients, said compound being advantageous over other NSAIDs and, in particular, the known active principle ketorolac tromethamine, comprising a single isomer that is pure and has a better therapeutic index, retaining its therapeutic activity by improving its physicochemical properties, such as solubility or stability, which translates into a decrease in the dose administered, reducing direct gastrointestinal side effects and the time required for the development of the desired therapeutic action. The invention is suitable for use as a medication for the treatment of pain of moderate to high intensity and can be administered in any form in the dose range from 0.5 milligrams to 30 milligrams.
机译:本发明涉及一种具有新的化合物,其特征在于它含有活性映体S - ( - )Ketorolac Tromethamine与其他药学上可接受的佐剂或赋形剂联合,所述化合物在其他NSAID中有利,特别是已知的活性原理Ketorolac Tromethamine ,包含纯的单一异构体,具有更好的治疗指标,通过改善其物理化学性质,例如溶解度或稳定性,其转化为施用剂量的降低,降低直接胃肠副作用和所需时间的溶解度或稳定性的治疗活性为了发展所需的治疗作用。本发明适用于用于治疗中度至高强度的疼痛的药物,并且可以以0.5毫克至30毫克的剂量范围的任何形式给药。

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