首页> 外国专利> NOVEL CHEMICAL COMPOUND CONTAINING ACTIVE ENANTIOMETER S-(-) KETOROLAC TROMETHAMINE FOR THE TREATMENT OF PAIN

NOVEL CHEMICAL COMPOUND CONTAINING ACTIVE ENANTIOMETER S-(-) KETOROLAC TROMETHAMINE FOR THE TREATMENT OF PAIN

机译:新型活性成分S-(-)酮咯酸曲美托胺化学化合物治疗疼痛

摘要

The invention relates to a new chemical compound characterised in that it contains the active enantiomer S-(-) ketorolac tromethamine combined with other pharmaceutically acceptable adjuvants or excipients, said compound being advantageous over other NSAIDs and, in particular, the known active principle ketorolac tromethamine, comprising a unique, pure isomer with a better therapeutic index, retaining its therapeutic activity by improving its physicochemical properties, such as solubility or stability, which translates into a decrease in the dose administered, reducing direct gastrointestinal side effects and the time required for the development of the desired therapeutic action. The invention is suitable for use as a medicament for the treatment of pain of moderate to high intensity and can be administered in any form, in the dose range varying from 0.5 milligrams to 30 milligrams.
机译:本发明涉及一种新的化合物,其特征在于它含有与其他药学上可接受的佐剂或赋形剂结合的活性对映体S-(-)酮咯酸三甲胺,所述化合物优于其他NSAID,尤其是已知的活性成分酮咯酸三甲胺包括具有更好治疗指数的独特,纯净的异构体,可通过改善其理化特性(例如溶解度或稳定性)来保留其治疗活性,从而降低给药剂量,减少直接胃肠道副作用以及治疗所需的时间所需治疗作用的发展。本发明适合用作治疗中度至高强度疼痛的药物,并且可以以任何形式施用,剂量范围为0.5毫克至30毫克。

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