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PRE-IMPLANTATION GENETIC SCREENING AND ANEUPLOIDY DETECTION
PRE-IMPLANTATION GENETIC SCREENING AND ANEUPLOIDY DETECTION
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机译:预注入遗传筛选和交氮化检测
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摘要
Provided herein are methods for determining ploidy of an embryo. The methods can include the steps of amplifying, using a primer pair that amplifies a plurality of human genomic loci, nucleic acid from a preimplantation embryo to generate a plurality of amplicons, sequencing the amplicons to generate a plurality of sequence reads, matching the sequence reads to the genomic loci and counting a number of matches, and determining chromosome count based on the number of matches. Also provided herein are systems for determining chromosome count comprising a processor coupled to a tangible memory subsystem storing instructions. When executed by the processor, the instructions cause the system to implement the methods provided.
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