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NANOZYME LINKED OLIGO PROBE SORBENT ASSAY (NLOPSA) FOR THE DETECTION OF NUCLEIC ACID BIOMARKERS
NANOZYME LINKED OLIGO PROBE SORBENT ASSAY (NLOPSA) FOR THE DETECTION OF NUCLEIC ACID BIOMARKERS
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机译:纳佐中的寡核糖探针吸附剂测定(NLOPSA)检测核酸生物标志物
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摘要
The invention provides a nanozyme for detecting one or more nucleic acid biomarkers and method for preparation thereof. The nanozyme includes a metallic nanoparticle, and a plurality of single-stranded oligonucleotide probes with thiol modification at a 5' end thereof, wherein each of the single-stranded oligonucleotide probes are conjugated via thiol chemisorption on the nanoparticle surface. The present invention also discloses nanozyme linked oligo probe assay (NLOPSA) for detection of one or more nucleic acid biomarkers.
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