TRIANTENNARY N-ACETYLGALACTOSAMINE MODIFIED HYDROXYL POLYAMIDOAMINE DENDRIMERS AND METHODS OF USE THEREOF

摘要

It has been established that dendrimers conjugated or complexed with the carbohydrate triantennary N-Acetylgalactosamine (triantennary-β-GalNAc) selectively accumulate within hepatocyte cells and selectively deliver therapeutic, prophylactic or diagnostic agents to the liver. Compositions of dendrimers complexed with triantennary-β-GalNAc and one or more agents to prevent, treat or diagnose a liver injury, liver disease or liver disorder in a subject in need thereof, and methods of use thereof, have been developed. The compositions are particularly suited for treating and/or ameliorating one or more symptoms of nonalcoholic fatty liver disease (NAFLD) and liver cancer, with decreased toxicity.