An object of the present invention is a method for producing human A1 astrocytes, which comprises inducing human A1 astrocytes from human astrocytes other than human A1 astrocytes; human A1 obtained by the above-mentioned method for producing human A1 astrocytes. To provide a method for evaluating a test substance using astrocytes; and the human A1 astrocytes described above. According to the present invention, there is provided a method for producing human A1 astrocytes, which comprises a step a of culturing human astrocytes other than human A1 astrocytes in the presence of TNFα and IFNγ.
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