Treatment of cancer using CD33 chimeric antigen receptor

摘要

Problem to be solved: to provide a composition and a method for treating the disease related to the expression of CD33.Solution for use in methods of treating myelodysplastic syndromes (MDS) in mammalsA group of immune effector cells that contain chimeric antigen receptorsThe car is a CD33 binding domainFilm transmembrane domainAnd intracellular signal transduction domainMDSIntractable anemia;Intractable anemia with cyclic iron blast;(c) refractory anemia with excess buds;(d) refractory anemia with excess buds in transformationOr(E) containing one or more of chronic myelomonocytic leukemia (CML)It is a group of immune effector cells.No selection