Antibody therapy for transthyretin (TTR) amyloidosis and human derived antibodies

摘要

A novel human derived antibody that is specific for transthyretin (TTR) and is preferably capable of binding to misfolded TTR species, misaligned TTR and / or aggregated TTR species Provide a method associated therewith.Human wild type TTR protein obtained by purification from human plasma and wild type TTR protein and mutant TTR protein obtained by recombination expression Provides a specific antibody used in both native conformation and misfold aggregated conformations to identify TTR targeted antibodies.No selection