Non neuronal SNARE cleavable botulinum neurotoxin

摘要

Non neuronal SNARE cleavable botulinum neurotoxinThe present invention provides a modified botulinum neurotoxin A (BoNT / a) L chain protease with its use for disconnecting hsnap-23, which demonstrates enhanced cleavage of human SNAP-23 (hsnp-23) in comparison with unaltered (wild type) BoNT / a chain proteases.