The present invention provides a modified botulinum neurotoxin A (BoNT/A) L-chain protease that demonstrates enhanced cleaveage of human SNAP-23 (hSNAP-23) relative to unmodified (wild-type) BoNT/A L-chain protease, together with the use thereof for cleaving hSNAP-23.
展开▼
机译：本发明提供了修饰的肉毒神经毒素A（BoNT / A）L链蛋白酶，与未修饰的（野生型）BoNT / A L链蛋白酶相比，其证明了人SNAP-23（hSNAP-23）的裂解增强。其在切割hSNAP-23中的用途。
展开▼
