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GENERATION OF KIDNEY GLOMERULAR SPECIFIC ENDOTHELIAL CELLS AND METHODS OF USE
GENERATION OF KIDNEY GLOMERULAR SPECIFIC ENDOTHELIAL CELLS AND METHODS OF USE
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机译:肾肾小球特异性内皮细胞的产生和使用方法
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摘要
The present disclosure is directed to method of generating human glomeruli endothelial cells (HGECs) from human endothelial cells (ECs), comprising expressing in human ECs an exogenous nucleic acid encoding a T-box transcription factor 3 (Tbx3), alone or in combination with one or more of PR domain zinc finger protein 1 (Prdm1), GATA Binding Protein 5 (Gata5) and Pre-B-Cell Leukemia Transcription Factor 1 (Pbx1). Disclosed also are HGECs produced by the methods of the instant disclosure, as well as methods for using the same.
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