The Effects of Glomerular Endothelial Cell Autophagy on Diabetic Nephropathy

摘要

Diabetic nephropathy is one of the most common causes of end-stage renal disease worldwide and is associated with increased mortality in patients with type 1 and type 2 diabetes.Autophagy is a highly conserved"autophagy"pathway and is an important mechanism for maintaining glomerular and tubular homeostasis.Emerging evidence suggests that targeted autophagy pathway activation and restoration of autophagy activity may have renal protection.Glomerular endothelial cells are an important key factor in the development of diabetic nephropathy.Endothelial dysfunction is involved in the development of diabetic and non-diabetic glomerular injury and renal fibrosis.Evidence of glomerular endothelial dysfunction in the late stages of diabetic nephropathy,such as thrombotic microangiopathy,including impairment of glomerular capillary microaneurysms and glomerular membrane lysis autophagy,is related to the pathogenesis of diabetic nephropathy.Here,we mainly introduced the research progress of the effects of glomerular endothelial cell autophagy on diabetic nephropathy.