ANTIPLATELET ACTIVITY OF CRUDE EXTRACT OF SEEDS OF ACANTHUS MOLLIS AND ITS COMPONENTS

摘要

FIELD: pharmaceutical industry. ;SUBSTANCE: group of inventions relates to the pharmaceutical industry and namely to the use of the extract and its components to inhibit the aggregation of human platelets. The use of a methanol extract of Acanthus mollis seeds for the inhibition of human platelet aggregation mediated by the arachidonic acid pathways and the PAR-1 receptor, where the extract contains 2-O-β-D-glucopyranosyl-4-hydroxy-1,4-benzoxazin-3-one (dimer ) (DIBOA-Glc), isoverbascoside and verbascoside. Disclosed is the use of 2-O-β-D-glucopyranosyl-4-hydroxy-1,4-benzoxazin-3-one (dimer) (DIBOA-Glc) at a concentration of 1 mg / ml, which inhibits arachidonic acid-induced platelet aggregation in humans, or isoverbascoside in a concentration of 1 mg / ml inhibiting human platelet aggregation mediated through the PAR-1 receptor pathway, or a combination of DIBOA-Glc with isoverbascoside, or a combination of DIBOA-Gl with isoverbascoside and verbascoside at a concentration of 1 mg / ml for each substance that inhibits human platelet aggregation, mediated by the arachidonic acid and PAR-1 receptor pathways to inhibit human platelet aggregation. ;EFFECT: use of the above-described extract and its components is effective for inhibiting the aggregation of human platelets. ;2 cl, 6 dwg, 1 tbl