(4S, 4As, 5aR, 12as) - 4-dimethylamino-3,10,12,12a-tetrahydroxy-7 - ((methoxy (methyl) amino) - methyl - 1,11-dioxo-1,4,4a, 55A, 6,11, Crystal salt of 12a-octahydro-naphthalene-2-carboxylic acid amide and method for using it

摘要

To provide tetracycline compounds as an active pharmaceutical ingredient having improved stability.SOLUTION: The invention provides a crystalline salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide, where the salt is selected from the group consisting of monohydrochloride, monomesylate and crystalline monosulfate.SELECTED DRAWING: Figure 1