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METHOD FOR PREPARING HYDROXYL COMPOUND, DEUTERATED COMPOUND THEREOF, AND TRITIATED COMPOUND THEREOF
METHOD FOR PREPARING HYDROXYL COMPOUND, DEUTERATED COMPOUND THEREOF, AND TRITIATED COMPOUND THEREOF
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机译:制备羟基化合物的方法,其氘化化合物及其氚化合物
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摘要
Disclosed is a method for preparing a compound I. The method comprises a reaction system comprising a compound II, which contains a carbon-oxygen double bond, and further comprising water, deuterated water, or tritiated water, which is prepared in order to obtain compound I. The method comprises reacting compound II containing the carbon-oxygen double bond with water, deuterated water, or tritiated water in the presence of metallic magnesium and an alkyl halide. The method is the first to use metallic magnesium as a reducing agent and an alkyl halide as an initiator to achieve polarity reversal of a carbonyl compound; the carbonyl compound is further reduced to prepare a compound I core skeleton comprising a hydroxyl-containing compound, a deuterated compound or a tritiated compound thereof.
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