TYPE V PHOSPHODIESTERASE INHIBITOR COMPOSITIONS, METHODS OF MAKING THEM AND METHODS OF USING THEM IN PREVENTING OR TREATING ELEVATED PULMONARY VASCULAR PRESSURE OR PULMONARY HEMORRHAGES

摘要

Methods of preventing or treating elevated pulmonary vascular pressure or exercise-induced pulmonary hemorrhage in mammals are provided, the methods comprise administering compositions comprising type V phosphodiesterase inhibitors and an organic base (e.g., meglumine) to the mammal. Compositions, kits and methods of making type V phosphodiesterase inhibitor are also provided. In one embodiment, the composition comprises E-4021, which is sodium 1-[6-chloro-4-(3,4-methylenedioxybenzyl)-aminoquinazolin-2- yl]piperidine-4-carboxylate sesquihydrate and meglumine.