Compound, process for preparing a compound, composition, use of a compound, and methods for treating or preventing a disease in a mammal where a phosphodiesterase isoenzyme inhibitor and / or a bronchodilator should be expected to be beneficial for the treatment or prevention of asthma in a mammal and for the treatment or prevention of chronic obstructive pulmonary disease (copd) in a mammal

摘要

"COMPOUND, PROCESS TO PREPARE A COMPOUND, COMPOSITION, USE OF A COMPOUND, AND METHODS FOR THE TREATMENT OR PREVENTION OF A DISEASE IN A MAMMALIAN WHERE TO EXPOSE AN INHIBITOR OF PHOSPHODIESTERASE AND / OR A BRONCODYLOSIS, OR BRONZODYCHEMISTRY FOR THE TREATMENT OR PREVENTION OF ASTHMA IN A MAMMALIAN AND FOR THE TREATMENT OR PREVENTION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) IN A MAMMALIAN ". The compounds of the general formula (I) in which each of R ^ 1 ^ ^ and R ^ 2 ^ ^ independently represents a C ~ 1-6 ~ alkyl or C ~ 2-7 ~ acyl group; X represents OCH ~ 2 ~ or a CR ^ 3 ^ R ^ 4 ^ group, each of R ^ 3 ^ or R ^ 4 ^ independently representing a hydrogen atom or a C ~ 1-3 ~ alkyl group; R5 represents a hydrogen atom or a C ~ 1-3 ~ alkyl, C ~ 2-3 ~ alkenyl or C ~ 2-3 ~ alkynyl group; R ^ 3 ^ represents a hydrogen atom or a C ~ 1-6 ~ alkyl, C ~ 2-6 ~ alkenyl, C ~ 2-6 ~ alkynyl, amino, C ~ 1-6 ~ amino, dialkyl (C ~ 1-6 ~) amino or C ~ 2-7 ~ acylamino; each of R ^ 7 ^ and R ^ 8 ^ independently represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C ~ 1-6 ~ alkyl, C ~ 2-6 ~ alkenyl, C ~ 2-6 ~ alkynyl, C ~ 2-7 ~ acyl, C ~ 1-6 ~ alkylthio, C ~ 1-6 ~ alkoxy, C ~ 3-6 ~ cycloalkyl; R ^ 9 ^ represents a hydrogen or halogen atom or a hydroxy, trifluoromethyl, C ~ 1-6 ~ alkyl, C ~ 2-6 ~ alkenyl, C ~ 2-6 ~ alkynyl, C ~ 2-7 ~ acyl group, C ~ 1-6 ~ alkylthio, C ~ 1-6 ~ alkoxy or C ~ 3-6 ~ cycloalkyl, or salts thereof are useful for the treatment of respiratory disorders such as asthma. The compounds of the invention have a longer duration of action than the known compound trequininsin (9,10-dimethoxy-3-methyl-2-mesitylimino-2,3,6,7-tetrahydro-4H-pyrimido [6, 1 -a] isoquinolin-4-one) and threquinsin does not taste very bitter.