Molecules with altered neonatal Fc receptor binding and enhanced therapeutic and diagnostic properties

摘要

The neonatal Fc receptor binding is modified to provide molecules with enhanced therapeutic and diagnostic characteristics.The present invention comprisesThe half life in vivo is(e.g.IgG steady regions or derived from human IgG such as human IgG1Change (increase or decrease) due to the presence of its FcRn bond fragment, such as the FC or hinge Fc regionProteinEspecially containing immunoglobulinsAt least the CH3 domain provides a molecule having a modification of one or more amino acid residues.No selection