Enhanced culture of tumor infiltrating lymphocytes (TIL) by adenosine A2A receptor antagonists and therapeutic combination of IL and adenosine A2A receptor antagonists

摘要

VipadanantCpi-444 (sifola denant)Sch58261Syn115ZM 241385Sch420814A method for expanding culture of tumor infiltrating lymphocytes (TIL) in the presence of adenosine A2A receptor (A2AR) antagonists, such as xanthine superfamily A2AR antagonists or related adenosine receptor 2A antagonists, and for treating disease such as cancer The use of expanded cultured til is disclosed herein.In addition, therapeutic combinations of the IL and A2AR antagonists, including compositions and their use in the treatment of diseases such as cancers, are disclosed herein.