Cali chair sewing compound - carrier conjugate

摘要

PROBLEM TO BE SOLVED: To provide methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug load significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF).;SOLUTION: Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also disclosed. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also disclosed.;SELECTED DRAWING: None;COPYRIGHT: (C)2017,JPO&INPIT