Production Methods of Immune-tolerant Extracellular Vesicles containing fetal-derived primal immunoglobulins

摘要

The present invention is Immunoglobulin M, Immunoglobulin A, Immunoglobulin D, Immunoglobulin G, Immunoglobulin G, Immunoglobulin G3, and Immunoglobulin E. Containing, extracellular vesicles derived from fetal stem cells having immune tolerance properties; A method of preparing fetal stem cell-derived extracellular vesicles having the above immune tolerance characteristics in a culture condition similar to that of the body during pregnancy; A pharmaceutical composition for preventing or treating infectious diseases caused by foreign infectious agents including the extracellular vesicles; It relates to a composition for enhancing innate immunity. The extracellular vesicles containing the embryonic stem cell-derived primordial immunoglobulin of the present invention contain various natural antibodies and complement proteins that can immediately respond to foreign infectious agents such as viruses, bacteria, and pathogens. The disease can be effectively treated and prevented, and it can be used for the treatment of infectious diseases without side effects by promoting the production of antibodies that can be delivered to the patient's immune system and react immediately to various foreign antigens.