Progress in Understanding the Functional Roles of Extracellular Vesicles in Reproduction

摘要

Exosomes,a type of extracellular vesicles(EVs),were first discovered in sheep reticulocytes in 1983[1],and after four years,the name‘exosome’was officially given to them.A variety of cells secrete exosomes under both normal and pathological conditions.Exosomes are mainly products of themultivesicular body formed by intracellular lysosomal invagi nation,and released into the extracellular space by fusion of the outer membrane of the multivesicular body with the cell membrane.