Bispecific antigen-binding construct targeting HER2

摘要

PROBLEM TO BE SOLVED: To provide a double paratopic antigen-binding construct that specifically binds to HER2. A dual paratopic antigen-binding construct that specifically binds to HER2 has one antigen-binding portion that binds to ECD2 of HER2, a second antigen-binding portion that binds to ECD4 of HER2, and Fc. including. At least one of the antigen-binding moieties is scFv. Double paratopic antigen-binding constructs can be used in the treatment of cancer. [Selection diagram] Fig. 1