Antifibrotic agents and biomarkers of fibrosis

摘要

An object of the present invention is to provide a molecule important for the onset of fibrosis and a substance capable of suppressing fibrosis. A biomarker for fibrosis, which consists of RNA-binding motif protein 7 (RBM7), is useful as a biomarker for diagnosing fibrosis. A method for detecting fibrosis, which comprises the step of detecting RBM7 in a biological sample derived from a test subject, preferably using an anti-RBM7 antibody, is useful for diagnosing fibrosis. In addition, antifibrosis agents including at least one nucleic acid drug selected from the group consisting of substances that suppress the expression of RBM7, preferably siRNA, shRNA, dsRNA, miRNA, and antisense nucleic acids for RBM7, are used for treating fibrosis. It is useful for.