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SITE-SPECIFIC ANTIBODY-DRUG GLYCONJUGATES AND METHODS
SITE-SPECIFIC ANTIBODY-DRUG GLYCONJUGATES AND METHODS
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机译:特异性抗体 - 药物甘油缀合物和方法
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摘要
Compounds, compositions, and methods are provided for covalently linking an antibody or an antibody fragment to a cargo molecule, such as a therapeutic or a diagnostic agent, using a combination of enzymatic glycan remodeling and click chemistry. The method allows a cargo molecule to be selectively and efficiently attached post-translationally to an antibody or an antibody fragment. Also provided are antibody drug conjugates, methods of making, and uses thereof.
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