HYPOXIA-INDUCIBLE FACTOR-2A AS A TARGET IN PREVENTION/TREATMENT OF PARKINSON'S DISEASE

摘要

The present invention provides hypoxia-inducible factor-2α (HIF-2α) as a target in the prevention/treatment of Parkinson's disease (PD). It is the first time to report the target that illustrated mechanisms of iron metabolism in astrocytes, accordingly to confirm the similarities and differences of iron traffic between astrocytes and neurons, leading to indicated the iron source of iron deposition in dopaminergic (DA) neurons and make sure the cause of iron is unevenly distributed in different brain regions, as well as the effects of glias on the role of iron traffic in neurons. It is HIF-2α, regulates the iron traffic in astrocytes. Therefore, not only a new action target HIF-2α is provided for preventing/treating PD iron deposition, but also a brand-new research thought and experimental evidence are provided for the iron transport mechanism of the astrocytes as the high iron source of nerve cells.