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Base composition for microneedle patch and microneedle patch containing this base composition

机译:微针贴剂的基础组合物和含有该基础组成的微针贴剂

摘要

PROBLEM TO BE SOLVED: To not only smoothly release a microneedle patch in a manufacturing stage, but also to obtain desired flexibility, flatness, flexibility and skin adhesion in a use stage, and to obtain moisture resistance in a storage stage. Providing a base composition for a microneedle patch and a microneedle patch containing the base composition. SOLUTION: The first HPMC contains a first hydroxypropyl methylcellulose (HPMC), a second HPMC, and a polyvinylpyrrolidone / vinyl acetate copolymer (PVP / VA), and the viscosity of the first HPMC is larger than the viscosity of the second HPMC. A base composition in which the weight ratio of the first HPMC to the second HPMC is 1: 0.1 or more and 1: 1.2 or less, and the amount of PVP / VA is 0.25% by weight or more and 2% by weight or less. [Selection diagram] None
机译:要解决的问题:不仅在制造阶段中平滑地释放微针贴片,还可以在使用阶段获得所需的柔韧性,平坦度,柔韧性和皮肤粘附,并在储存阶段获得耐湿性。为微针贴剂和含有基础组成的微针贴剂提供碱性组合物。溶液:第一HPMC含有第一羟丙基甲基纤维素(HPMC),第二HPMC和聚乙酸吡咯烷酮/乙酸乙烯酯共聚物(PVP / VA),并且第一HPMC的粘度大于第二HPMC的粘度。一种基础组合物,其中第一HPMC与第二HPMC的重量比为1:0.1或更高,1:1.2以下,PVP / Va的量为0.25重量%或更高,2重量%或更低。 [选择图]无

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