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TARGETING P73 FOR CANCERS RESISTANT TO BH3 MIMETICS
TARGETING P73 FOR CANCERS RESISTANT TO BH3 MIMETICS
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机译:针对P73的癌症耐受BH3模拟物的癌症
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摘要
Embodiments of the disclosure encompass methods and compositions related to overcoming or preventing cancer resistance to anti-apoptotic proteins, for example BH3 mimetics. The disclosure provides methods for modulating p73 to reduce cancer resistance to BH3 mimetics including inhibitors of Bcl-2, Bcl-xL, Mcl-1, Bcl-W, A1/BFL-1, or a combination thereof. In specific embodiments, targeting isoforms of p73, such as TAp73 or DNp73, results in reduction of cancer resistance to BH3 mimetics to allow effective treatment of hematological cancers.
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