首页> 外国专利> Compositions and Methods for Enhancement of Homology-Directed Repair Mediated Precise Gene Editing by Programming DNA Repair with a Single RNA-Guided Endonuclease

Compositions and Methods for Enhancement of Homology-Directed Repair Mediated Precise Gene Editing by Programming DNA Repair with a Single RNA-Guided Endonuclease

机译：通过用单个RNA引导的内切核酸酶编程DNA修复来增强同源定向修复介导的精确基因编辑的组合物和方法

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摘要

The present invention includes compositions and methods for enhancing homology directed repair (HDR) and/or reducing non-homologous end joining (NHEJ) in a cell following CRISPR-mediated editing.

机译：本发明包括用于在CRISPR介导的编辑后的细胞中增强同源性修复（HDR）和/或减少在细胞中的非同源末端接合（NHEJ）的组合物和方法。

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公开/公告号US2021130818A1

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公开/公告日2021-05-06

原文格式PDF
申请/专利权人 YALE UNIVERSITY;ZHEJIANG UNIVERSITY;
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申请/专利号US201817257476
发明设计人 SIDI CHEN;LUPENG YE;CHENGKUN WANG;FENG HAN;
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申请日2018-07-04
分类号C12N15/11;C12N15/90;C12N9/22;C12N15/86;C12N7;
国家 US
入库时间 2022-08-24 18:35:10

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