Processes to prepare elongated 2-ketoacids and C5-C10 compounds therefrom via genetic modifications to microbial metabolic pathways

摘要

Genetically modified isopropylmalate synthases, processes for preparing a C₇-C₁₁ 2-ketoacids utilizing genetically modified isopropylmalate synthases, and microbial organisms including genetically modified isopropylmalate synthases are described. The genetically modified isopropylmalate synthases, processes for preparing a C₇-C₁₁ 2-ketoacids, and microbial organisms including genetically modified isopropylmalate synthases can be particularly useful for producing corresponding C_{n_1} aldehydes, alcohols, carboxylic acids, and C_{n_2} alkanes both in vivo and in vitro.