Heterocyclic compounds as inhibitors of the TYRO3, AXL and MERTK (TAM) family of receptor tyrosine kinases

摘要

The following compounds of formula (I) and their tautomers, stereoisomers, isotopologues or pharmaceutically acceptable salts are disclosed, in which variables R1, rings A, L, W, V and Each of G is defined herein. Diseases or disorders mediated by Tyro3, Axl and / or Mer kinase using compounds of formula (I) or tautomers, stereoisomers, isotopologues or salts thereof, and pharmaceutical compositions containing them. Also disclosed are methods of treating.